Catalogue 2020 - 2021

HS 315 Protein Folding, Misfolding & Disease

Credits

3 cr.

Prerequisite

BIO 108, CHEM 106, and Junior Standing, or permission of instructor.

Course Description

This course covers the effects of the alteration of the folded protein structure as a consequence of environmental stress, genetic mutation, and/or infection. Misfolded proteins can stick together and fall out of solution in a process known as aggregation. In many protein aggregation diseases, misfolded proteins self-associate, forming fiber-like aggregates that cause brain cell death and dementia. The molecular and biochemical basis of the prion diseases, which include bovine spongiform encephalopathy (mad cow disease), Creutzfeldt-Jakob disease and kuru will be examined. Other classes of misfolding diseases such as Alzheimer's disease, Parkinson's disease, Cystic Fibrosis, and cancer will be discussed including possible detection methods and therapies.

Distribution

MR

Fee